John Cryer has finally spoken out about Charlie Sheen and his departure from “Two and a Half Men.”

On the “Late Show” last night, Cryer told Letterman:

“It’s as much a mystery to me as to everyone, I think. My favorite moment was I got a text from someone, saying, ‘Charlie Sheen just called Thomas Jefferson a p*ssy.’ I said, ‘I think things are getting out of hand.’

“We didn’t see where it was going,” Cryer went on. “This has never happened before. It wasn’t like, back in 1963, oh everyone remembers when Fred McMurray went bats*it and started talking about free mason ninjas and stuff. It was crazy! And Vivian Vance started urinating on the set of ‘Here’s Lucy.’ So nobody was prepared for this … None of us wanted to continue with the show if we felt it was hurting him, and there was a point when everyone felt like… there was no control here.”

When it was first announced that the show had been shut-down … Cryer reveals: “It was the end of the world for some people. There are a lot of fans of the show… it hit people hard.”

With Charlie no longer being a part of the show, Cryer wants him to get sober and spend time with his family.

“I want him to stay sober, I want him to be reunited with his family,” he said. “That would be the best thing.’

Peep the footage below: